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Cytochrome P450 2E1 catalyzes the conversion of APAP to a toxic metabolite, N-acetyl-p-benzoquinone imine

After eight weeks, leg heaviness was reported to be reduced by 60.4% in the Pycnogenol group compared to a reduction of 12.6% in the placebo group

The abundance of Enterococcus faecalis and Candida in the gut of patients with AH is strongly correlated with liver disease severity and mortality [198]