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What forms the bulk of the retail price2 of peptides is not the cost of manufacturing, but the capital infrastructure: the regulatory burden, the cold chain logistics, the pen device (which sometimes costs more than the drug itself), and, above all, the return needed to justify $9 billion in the initial R&D of these GLP-1 drugs
Nothing crazy, but enough to leave me with a nasty second-degree burn about the size of my palm
Determination of the receptorligand co-crystal structures and mutational studies have led to a two-step model of peptide binding and receptor activation 17,18,19,20
doi: 10.1016/S0140-6736(19)31149-3 71 RomeraICebrian-CuencaAAlvarez-GuisasolaFGomez-PeraltaFReviriegoJ
The study was funded by the National Institutes of Health (grants R01DK125260, P30DK116074, K99AR081618 and GM113854), the SPARK Translational Research Program at Stanford, Stanford Bio-X, the Stanford Maternal and Child Health Research Institute, the American Heart Association, a Stanford Medicine Dean's Fellowship Award, the Carlsberg Foundation, and the Wu Tsai Human Performance Alliance
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Theres going to be an explosion in just the sheer number of compounds and also the methods to make them. A hybrid approach Gellman has taken a different approach to novel GLP-1 drugs based on his synthetic beta peptides
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