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Since estrogen helps maintain healthy bones, lower levels can lead to bone loss and increased fracture risk
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Providing a treatment option that is proven to lower this cardiovascular risk is a major advance for public health. Around 5.5% of American adults have cardiovascular disease and 70% of Americans are classified as having overweight or obesity, making this a treatment that can potentially impact a portion of the population
Reconstituted tirzepatide from a lyophilized vial is a compounded or research-grade product that has not undergone the same regulatory validation
In PEGylation, polyethylene glycol (PEG) chains are attached
Pre-clinical studies have demonstrated mixed findings, including potential protective effects of GLP-1 RAs in the context of diabetic retinopathy, with GLP-1 receptors found in the RPE serving a neuroprotective role in conditions of high glucose
