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Melanocortin 1 receptor (MC1R) gene variants are associated with an increased risk for cutaneous melanoma which is largely independent of skin type and hair color

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Options for managing tolerance include a brief dose reduction for 4 to 8 weeks ("drug holiday" at a lower dose, not complete cessation), lifestyle optimization to maximize the medication effect, evaluation for other contributing factors (thyroid function, cortisol, sleep quality, medication interactions), and consideration of adding a complementary compound to address specific aspects of the plateau

This may contribute to reduced interest in high-calorie foods, though human clinical evidence in this area continues to evolve

doi: 10.1136/bmj.n71 13 HigginsJPAltmanDGGtzschePCJniPMoherDOxmanADet al