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On 24 November 2025, Novo Nordisk reported that oral semaglutide had failed to slow Alzheimers disease in the EVOKE and EVOKE+ trials, which together enrolled 3,808 participants and stand as the largest evaluation of this drug class in any neurodegenerative condition [1]

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106 The preproglucagon gene is transcribed to mRNA and then translated to form the preproglucagon protein (180aa residues), which is then cleaved in pancreatic alpha-cells, gut endocrine L-cells and neurons in the caudal brainstem and hypothalamus

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