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The phase 3 TRIUMPH-4 data showed these rates at 9 mg and 12 mg doses respectively: Nausea: 38.1% and 43.2% (vs 10.7% placebo) Diarrhea: 34.7% and 33.1% (vs 13.4% placebo) Constipation: 21.8% and 25.0% (vs 8.7% placebo) Vomiting: 20.4% and 20.9% (vs placebo) These numbers are higher than cagrilintide monotherapy across the board

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Melatonin may be more effective if your sleep struggles are tied to circadian rhythm issues, like jet lag or shift work, because it tells your body its bedtime

For a 75 to 90kg adult, that translates roughly to 190 to 900mcg daily, which brackets the 200 to 500mcg range being used in practice

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