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It also slows the rate at which food leaves the stomach, contributing to prolonged satiety after meals

What also matters clinically is bioavailability

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Consistent dosing plus targeted habits matter: structured programs tracked over 12 weeks show appetite and glucose improvements within weeks, but waist changes and imaging-confirmed visceral fat loss lag unless protein intake and resistance training preserve lean mass

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They contain a combination of naltrexone and bupropion, which work together to reduce appetite and control cravings