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GPs can prescribe B12 injections following appropriate investigation, which should include: Full blood count to identify macrocytic anaemia Serum B12 and folate levels to confirm deficiency (using laboratory-specific reference ranges) Methylmalonic acid and/or homocysteine when B12 results are borderline Intrinsic factor antibodies if pernicious anaemia is suspected Additional tests depending on clinical presentation (e.g., thyroid function, coeliac serology) When both B12 and folate deficiency are present, B12 should be replaced before folate to avoid precipitating subacute combined degeneration of the spinal cord

Clean the injection site: Clean the skin with an alcohol swab

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Any sort of GI problem (including hormone imbalances like thyroid problems) may limit absorption

For these dosages, a 1 ml syringe is often sufficient, providing the precision needed for proper administration

Example: I entered in 1ml syringe, 10mg powder, 3ml bac water and a 250mcg dose.It tells me where I need to measure my syringe at