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Conversely, patients who carry variants in hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13, rs72613567) and mitochondrial amidoxime-reducing component 1 (MARC1, rs2642438) are more protected than the general population (48, 49)
Pyroglutamate, a glutamate analogue and precursor, helps maintain intracellular glutamate concentrations and has also been linked to various osmoprotective roles 76
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