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Glycemic indexes (A1C, fasting blood glucose) and kidney function should be monitored during initiation of therapy and routinely throughout the treatment plan

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Recently, two mechanisms involved in the gut-brain axis have attracted increasing attention due to their role in the pathogenesis and progression of PD, namely, disruption of the composition of microorganisms living in the intestine (intestinal microbiome) and dysfunction of enteroendocrine cells, accompanied by impaired signaling through the GLP-1R [60]

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