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Kawamura K, Qi F, Kobayashi J

IGF-1 LR3 sustains receptor occupancy for hours, which changes downstream gene-expression kinetics and raises distinct safety considerations discussed in the pharmacokinetics section below [4]

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32, 14841495.10.1038/jcbfm.2012.33 81 LipsettM

Currently, more than thirty pharmacological drugs have been approved by the United States Food and Drug Administration (USFDA) and are available in the market (Perucca, 2021), as shown in Figure 1B