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The transcription factor nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) has been shown to induce energy expenditure and reduce adipose tissue growth, leading to prevention of dietary obesity and lowering adipogenesis, inflammation, and IR [47]

Side effects are usually gastrointestinal (nausea, diarrhea) but serious adverse events are relatively uncommon

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The predominant form that is found in human plasma is the CCK-33 form

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Intriguingly, amplification involves a switch in G protein coupling of the GHS-R from Galpha (11/q) to Galpha (i/o) by a mechanism consistent with agonist-dependent formation of GHS-R/D1R heterodimers