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Large studies, both national and international, did not identify a clear link between the two
IGF-1 LR3 has no FDA approval and is classified as a research compound, meaning it cannot be legally sold for human use in the US
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On one hand, social media might suggest these drugs are a "miracle" with no downsides
Researchers studying GCGR-driven energy expenditure or hepatic glucose output in cell models often use retatrutide alongside the other two as reference compounds to isolate the contribution of each receptor
If oral options are preferred, other SGLT2s such as canagliflozin or dapagliflozin are potential alternatives
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