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Preclinical studies in diet-induced obesity rodent models are ongoing to evaluate its efficacy, safety, and tolerability as a potential therapy for type 2 diabetes and obesity

doi: 10.1038/s41467-021-25509-3 256 WangEYMaoTKleinJDaiYHuckJDJaycoxJRet al

Yet, controversial outcomes on the efficacy of metformin have also been reported 21,22,23,24 , that might be attributed to heterogeneity of responses in some patient subgroups

doi: 10.3390/ijerph19084870

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