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Adding GIPR co-agonism (as in tirzepatide and retatrutide) introduces additional Gs signalling from a second receptor type expressed on adipocytes, beta cells, and hypothalamic neurones
Many patients love this treatment for its skin-lightening and brightening properties
A similar finding is plausible for retatrutide given similar albumin-binding kinetics, but prescribers should await phase 3 subgroup data before assuming equivalent behavior in decompensated cirrhosis
In Part 1, well explore key considerations for identifying appropriate GLP-1 candidates and highlight the importance of setting realistic weight loss expectations
Nutritional deficiencies: Nutrient deficiencies (such as iodine, zinc, vitamin D, or iron deficiency) may trigger hypothyroidism or autoimmunity
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