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People using oral contraception should either: Switch to a non-oral method, or Use a barrier method for 4 weeks after initiation and 4 weeks after each dose escalation Given the titration schedule, that can mean several months of backup contraception

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However, 1/10 the normal NAC rescue (solid blue) and 1/20 the normal NAC rescue (solid green) substantially delay the time of GSH rebound and decrease substantially the curves showing the time course of functional hepatocytes