Considering that this compound has been demonstrated to expand the GSH system along with a reduction in oxidative injury by the AKT/Nrf2 signaling pathway in the hearts of rats and H9C2 cells, the abovementioned enhanced TAC may cover GSH and GSH-dependent antioxidant enzymes [150,151,152]
10.1186/s13024-019-0341-5 65 TrenzT
Since GSH itself is susceptible to oxidation by certain substances, it protects the sulfhydryl groups in many proteins and enzymes and other molecules in the body from being oxidized by harmful substances, thus ensuring the normal physiological functions of proteins and enzymes and other molecules
Lipid peroxidation occurs when free radicals attack and damage cell membrane lipids, particularly PUFAs ( 2 O 2 , and OH, can initiate lipid peroxidation by oxidizing PUFAs in the cell membranes of intestinal epithelial cells
Radikal bebas yang berlebihan dapat menyebabkan stres oksidatif
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