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Molecular analysis of the growth hormone releasing hormone receptor gene (GHRHR) in isolated growth hormone deficiency: identification of a likely etiological mutation in the signal peptide

A 2025 systematic review and meta-analysis in JAMA Psychiatry found no overall increase in psychiatric side effects, including depression, with GLP-1 medications

[1] [2] It must be used in conjunction with a reduced-calorie diet and increased physical activity

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Dehydration can contribute to constipation

For overall recovery including body composition goals, GH or GH secretagogues might be considered