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This combined approach makes it easier for patients to consume smaller, nutrient dense portions without feeling constantly hungry
The Discovery and Development of Human GLP-1 Product details Product details Edition: 1 Latest edition Published: March 3, 2026 Language: English About the author About the author JH Jens Juul Holst Jens Juul Holst is Professor of Medical Physiology at the Department of Biomedical Sciences, University of Copenhagen
Strengths: Only semaglutide product Health Canada-approved for weight management Highest dose (2.4 mg) delivers the strongest average weight loss about 15% body weight over 68 weeks in STEP 1 [4] SELECT trial demonstrated 20% reduction in major adverse cardiovascular events [2] Five-step titration schedule helps manage GI side effects Limitations: Insurance coverage for weight management is inconsistent across provinces and private plans Higher dose means higher rates of nausea, vomiting and diarrhea during titration Out-of-pocket cost is roughly $380$500 per month [5] Read our Wegovy guide for titration tips and coverage advice
GLP-1 Agonists for Type 2 Diabetes: Are They Right for You
What does long-term treatment actually look like
