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Nutrition Research, 1997

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Glucose dependent insulin and glucagon secretion Semaglutide lowers high blood glucose concentrations by stimulating insulin secretion and lowering glucagon secretion in a glucose-dependent manner

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Similar results were also obtained by the Researching Cardiovascular Events with a Weekly Incretin in Diabetes (REWIND) trial, where the long-term treatment with dulaglutide was also found to reduce the incidence of moderate or severe erectile dysfunction in middle-aged men with T2DM [155]

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The treatment has been around for decades, but has had a rocky history: It was widely prescribed from the 1960s through 1990s before usage came to an abrupt halt in 2002, when the Womens Health Initiative published findings suggesting that hormone therapy increased the risk of breast cancer, heart disease, stroke, and blood clots

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