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According to the NIH Office of Dietary Supplements, functional B12 deficiency is most commonly seen in patients with one or more of the following: Age over 50 stomach acid production declines with age, and stomach acid is required to free B12 from food PPI or H2 blocker use reflux medications suppress the acid needed for B12 absorption Metformin use, which interferes with B12 absorption directly Vegan or vegetarian diets B12 is found almost exclusively in animal products Gut conditions including celiac, IBS, SIBO, and Crohns MTHFR mutations that affect how B12 is metabolized once absorbed Heavy alcohol use The symptoms of low B12 are easy to dismiss: fatigue, brain fog, low mood, tingling in the hands or feet, weakness, and shortness of breath on mild exertion

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Intramuscular B12 Injection Guidelines To get the most out of B12 therapy, knowing how to do intramuscular injections is key

The exact dose depends on your specific needs and what your doctor says

[8] [4] The body cannot produce B12 naturally, so it must be obtained through diet (primarily animal products) or supplementation

Vitamin B Complex can improve the immune system of all patients