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Paradoxically, activating the glucagon receptor in a controlled, pulsatile pharmacological fashion appears to increase energy expenditure, enhance fat burning in the liver, and promote thermogenesis, effects that purely GLP-1-based agents do not reliably produce

For example, Leung et al

It reduces appetite, slows gastric emptying and helps maintain sustained weight loss when combined with supervised nutrition and activity changes

Long-term steroids carry many potential risks, including bone fractures, effects on height and metabolism, and immunosupression

For real-world adherence, that's a bigger deal than it sounds

There is no universal answer