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Our team has observed that for studies focusing on long-term, sustained NNMT inhibition where slight variations in peak plasma concentration aren't catastrophic, the oral route might be sufficient
For a loading protocol of 2.5 mg twice per week, reconstituting with 2 mL gives 2.5 mg/mL, so each 2.5 mg dose is 100 units (the full syringe)
Systemic administration typically suits joint applications given the difficulty of accessing intra-articular spaces without specialized medical procedures
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