While circulating levels of PYY 3-36 are frequently reduced in individuals with obesity 31,32,33,34,35 , these levels typically return to those detected in average-weight individuals following a reduction in body weight and/or gastric bypass surgery 32,33,35
Notably, in the liver, FAT/CD36 is highly expressed in non-parenchymal cells in comparison to hepatocytes, thus FAT/CD36 might play more important roles in hepatic inflammation and fibrogenesis compared to lipid uptake
A systematic review of weight stigma and disordered eating cognitions and behaviors
Given the lack of safety data, most clinicians recommend considering alternative weight management approaches during lactation
Campolo, M
Some conditions warrant caution