The evidence is not hypothetical
Butyrate is the preferred fuel for colonocytes the cells that line and protect the gut
Semaglutide and cardiovascular outcomes in patients with obesity and prevalent heart failure: a prespecified analysis of the SELECT trial
Makeeva has even made TikTok videos about berberines effectsbut she has reservations about how the supplement has turned into a fad diet product
It works best when combined with healthy eating habits and regular physical activity.Noveltreat 0.25 mg Pre-filled Pen is used along with a reduced-calorie diet and increased physical activity to help lower the risk of major heart-related events, such as heart attack, stroke, or cardiovascular death, in adults who have established heart disease and also have obesity or overweight
More serious but rare complications include pancreatitis, gallbladder disease, and potential thyroid C-cell tumors (observed in rodent studies, with uncertain human relevance)