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Contraindications for Xigduo XR XIGDUO XR is contraindicated in patients with: Severe renal impairment (eGFR below 30 mL/min/1.73 m) or end-stage renal disease [see WARNINGS AND PRECAUTIONS ]

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GSH is synthesized in the cytosol of all nucleated cells and transported across organelles to support diverse metabolic cellular functions (1-2)

Reilly KM, Tuskan RG, Christy E, Loisel DA, Ledger J, Bronson RT, et al