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While a number of mechanistic studies have found that metformin lowers fasting blood glucose levels by suppressing hepatic glucose production [1,2,3], a substantial body of in vivo data suggest that much of the glucose-lowering action occurs at the level of the gastrointestinal tract, irrespective of its systemic bioavailability [3, 4]
Yes, but they must be monitored by a medical provider to prevent side effects and ensure sustained results
Kidney function markers stayed stable or improved
Routine monitoring should include: Blood glucose levels self-monitoring as individually advised by your diabetes team