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Wallerian degeneration, Wld S , and Nmnat

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This means that the surrounding tissue remain safe

Emotional deficits include increased anxiety and paranoia [177, 185,186,187], mood disorders [186], agitation and irritability [178, 188], and emotional blunting and disrupted emotional regulation [178]

Acneiform or skin changes have been reported with high-dose or frequent B12 administration, though the mechanism remains unclear