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Pancreatitis: This drug may cause inflammation of the pancreas, which may develop as ongoing stomach pain that sometimes spreads to the back

The most clinically documented interaction is with cyclosporine, where berberine can significantly increase blood levels, potentially requiring dose adjustments and therapeutic drug monitoring

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Degraded peptides do not typically cause severe adverse reactions, but they negate any anti-aging benefit and can sensitize skin in individuals prone to metal allergies