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These risk differences might be explained by additional mechanisms beyond the actions of GLP-1 RAs on vasculature, including the chronotropic effects of GLP-1 RAs which may blunt cardiac protection ( Unstable angina pectoris: An umbrella review of meta-analyses of RCTs including 56,004 patients with diabetes, prediabetes, and at high risk of diabetes, found no association between GLP-1 RAs and the risk of uAP (RR = 1.06, 95%CI = 0.931.21) when compared to placebo (Zhu et al., 2020)
Curr Med Res Opin (2010) 26(5):101322
Res 119 , 142158 (2016)
10.1111/j.1748-1716.2010.02122.x 57
However, insulin can stimulate carnitine transport to skeletal muscle [272], which is associated with the upregulation of OCTN2 transcript levels [273]
inhibition of reactive oxygen species-producing enzymes such as xanthine oxidase (XO) and nicotinamide adenine dinucleotide phosphate oxidase (NOX)
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