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Nature 615 , 292299 (2023)
PallardFVMarkovicJGarcaJLViaJ
Thus, in perfect agreement with the recent ADA-EASD consensus report [6], we also encourage the adoption of GLP-1RA plus SGLT2i combination therapy in T2DM patients with established ASCVD (coronary artery disease, cerebrovascular disease, or peripheral arterial disease) or multiple risk factors for ASCVD (i.e., age 55 years, obesity, dyslipidemia, hypertension, current tobacco use, left ventricular hypertrophy, and/or proteinuria) whose HbA1c remains suboptimal despite initial treatment with only one of these agents
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It consists of 15 amino acids and is known for its potential healing properties and tissue repair effects
Meldonium has been described as metabolized via 3-hydroxypropionic acid with formation of succinic acid ( Effects on oxidative stress and inflammation-linked mitochondrial dysfunction Hypoxia and intense exertion can promote inflammatory signaling and oxidative stress, contributing to mitochondrial dysfunction
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