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Presentations at the most recent ADA scientific sessions in 2024 included discussions of clear benefits to reduce liver fat in MASH (formerly called NAFLD) with tirzepatide (Loomba, NEJM, 2024) and a phase 2 trial with the triagonist (GLP-1/GIP/Glucagon), retatrutide (Sanyal, Nature Medicine, 2024)
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Treatment Once youre prescribed semaglutide, your provider starts you on a low dose and gradually increases it over time to help minimize side effects
Patients typically start at 0.25 mg weekly, then move to 0.5 mg in week five, 1.0 mg in week nine, 1.7 mg in week thirteen, and finally 2.4 mg in week seventeen
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