Works through different neural pathways than GLP-1, which is why combining cagrilintide with semaglutide (CagriSema) enhances weight loss beyond either alone
International journal of cosmetic science , 27 (3), 155160
doi: 10.1038/nrendo.2012.140 2 MahapatraMKKaruppasamyMSahooBM
van Raalte DH, Bjornstad P, Persson F et al (2019) The impact of sotagliflozin on renal function, albuminuria, blood pressure, and hematocrit in adults with type 1 diabetes
Emerging agents like Tirzepatide, which activates both GLP-1 and GIP receptors, and Orforglipron, a nonpeptide oral GLP-1 agonist in phase 2 trials, further expand the therapeutic potential of this class (23)(24)
Therefore, BMP4 becomes a potential therapeutic target in CRC, especially in a diabetic context where high blood glucose significantly affects cancer progression through the BMP4 pathway