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Effect of melatonin on phase I and II biotransformation enzymes in streptozotocin-induced diabetic rats

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Take a one week break after each 3 months of continuous treatment

Research indicates that while 30 mg phentermine shows superior results at 3 months, the 15 mg dose provides comparable outcomes by 6 monthssuggesting the lower dose may offer an optimal balance of efficacy and tolerability for long-term use

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Preclinical data and practitioner observations suggest effects may occur within days