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While there may be some resistance to the conduction of clinical trials of pharmacological interventions in these clinical populations, the mechanistic profile of GLP-1RAs clearly suggests that these medications may play a role in the treatment of certain specific eating disorders, such as BED
To explore pharmacologically controlled activation, we leveraged the melatonin-deficient background of C57BL/6J mice 49 , where basal GLP-1 expression remained below the ~50 pM threshold required for therapeutic efficacy 53
Kidney Blood Press Res 38 (1): 31-41
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