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The more efficient conjugation of the QIs to GSH may have reduced covalent modification of cellular macromolecules, like ER proteins Grp78/Bip ( Although reactive QI formation has been associated with AQ-induced (cyto)toxicity in vitro ( in vivo (S5), although DNA ( Figure 6 ) is consistent with the lack of activation of an adaptive oxidative stress response pathway observed here and in a previous study ( Figure 7 , AQ-QI and DEAQ-QI exposure resulted in activation of the ER stress response

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These pauses, often caused by a collapse of the airway (obstructive sleep apnea) or a failure of the brain to send the correct signals to muscles controlling breathing (central sleep apnea), can last for seconds or even minutes