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Mechanical Load and GLP-1 Exercise Skeletal muscle depends on mechanical stress for its growth and maintenance a principle known as mechanotransduction

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Under homeostatic conditions, transient activation of NRF2 is cytoprotective, allowing for adaptation to various cell intrinsic (i.e., reactive oxygen species (ROS) generated by mitochondrial function) and extrinsic (i.e., xenobiotic) stressors (Kensler et al, 2007

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