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This level of responsiveness is virtually unprecedented in metabolic clinical research, suggesting that the triple-agonist approach may capture a wider range of biological phenotypes that might be resistant to single or dual agonism

Knauf, C

However, when RBCs are saturated with carbon monoxide, Prx2 was observed only in the active form in the cytosol and none in the oxidized form, suggesting that Prx2 is acting specifically to protect Hb, shifting its function from peroxidase to chaperone

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