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This multi-action mechanism helps manage blood glucose while promoting weight loss, setting Tirzepatide apart from other GLP-1 agonists that target only the GLP-1 pathway

10.1016/j.prp.2018.12.013 99 TanS.LiR.DingK.LobieP

The Diabetes Prevention Programme, a large RCT comparing Metformin, ILI and placebo, indicated that after 21 years of follow-up, there was no significant reduction in cancer incidence comparing ILI to placebo (RR 0.96, 95% CI = 0.791.18) [14]

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We also confirmed that the excitatory effect of exendin-4 on neurons in the IML region (4 preganglionic neurons and 1 interneurons) was blocked by GLP-1 receptor antagonist (1015 min pretreatment of antagonist followed by 100 nM exendin-4 plus antagonist) (Fig