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1 Some common GLP-1 drugs approved by the FDA to help treat weight loss include: Semaglutide injection (Wegovy) 1 Liraglutide (Saxenda) 1 Tirezepatide (Zepbound) 1 Common Digestive Side Effects of GLP-1 Medications Gastrointestinal side effects of GLP-1 medications are not uncommon and can include: Gas (flatulence) and gas pains 1,2 Bloating 1,2 Constipation 1,2 Diarrhea 1,2 How to Manage GLP-1 Gas and Bloating Caused by Weight Loss Drugs Gas and bloating due to constipation caused by weight loss medications can be annoying (and smelly) in your daily life, but they can be easily remedied on your own