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A transient peptide can produce a pulse of activity instead of a sustained alteration

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Human NAT2 is a xenobioticmetabolising enzyme that provides a major route of detoxification of drugs such as isoniazid (an antituberculotic drug), hydralazine and endralazine (antihypertensive drugs), a number of sulphonamides (antibacterial drugs) (Kawamura et al., 2005), procainamide (antiarrhythmic drug), aminoglutethimide (an inhibitor of adrenocortical steroid synthesis), nitrazepam (a benzodiazepine) and the antiinflammatory drug dapsone (Ginsberg et al., 2009, Butcher at al., 2002)

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On the latter point, it is important to keep in mind that these results are limited to the specific timeframe we studied and to the specific experimental conditions of this study (i.e., acute cannabis administration in cannabis users)

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