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This difference was likely attributable to the insufficient inhibition of excessive GJ proteins in hepsin / mice in response to the lower 2APB dose of 1 mg/kg, lending further support to the hypothesis that hepsin may help reduce APAP toxicity by regulating the expression of hepatic GJ proteins

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Biochem Biophys Res Commun 405 , 173179, doi: 10.1016/j.bbrc.2011.01.002 (2011)