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In T eff cells, the metabolic state is changed to increasingly rely on glycolysis, as these cells upregulate GLUT1, increase glucose intake
GPx-1 is particularly important in the antioxidant defense of vascular walls and neural cells, especially under oxidative stress conditions, while GPx-2 serves as the predominant isoform in the lungs, with expression regulated by the transcription factor Nrf2
IV doses of 25-400 mcg/kg for safety studies Important: These are experimental doses used in animal studies and cannot be extrapolated to other species due to significant differences in metabolism, pharmacokinetics, receptor expression, peptide degradation rates, and tissue distribution patterns
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