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Most side effects of sermorelin are mild, but ongoing monitoring (including periodic blood tests for IGF-1 and other parameters) is part of therapy to ensure safety

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Obesity Reviews (2004) 7

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This remarkable selectivity stems from 5-amino-1MQs specific interaction with the nicotinamide-binding pocket of NNMT, rather than the SAM-binding site common to many methyltransferases

Management should focus on eliminating repeated exposure and reducing inflammation, often with topical or oral steroids when appropriate. A dermatologist can prescribe those medications