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Phase 2 trials test a drug on a few hundred participants over a year or so to establish efficacy and identify side effects

The Humira patent thicket is the canonical example: AbbVie assembled more than 250 patents on adalimumab, creating a barrier that kept biosimilars out of the U.S

The manufacturing environment must meet cleanliness and contamination prevention standards

It May Improve Energy and Endurance Similar to other caffeinated, antioxidant-rich beverages like coffee and green tea, yerba mate has the ability to boost energy, physical performance, and muscle endurance, Dr

Constipation and diarrhea also occur, sometimes in alternating patterns

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