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Reducing the expression of UA transporter proteins in the setting of insulin resistance down regulates blood UA levels (Zhang et al., 2021)
It is that simple
Those who have successfully implemented sustainable changesincluding regular physical activity (UK Chief Medical Officers recommend at least 150 minutes of moderate-intensity activity weekly), improved dietary patterns, and behavioural strategies for weight managementmay have better outcomes if discontinuing GLP-1 therapy
Dose reduction remains the most reliable solution if water retention becomes genuinely bothersome
Very few post-surgical patients need doses above 8 mg
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