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doi:10.3762/bjnano.12.77
Updated April 16, 2025
That trial (announced in 2023) is the first to prove that treating obesity pharmacologically can prevent cardiovascular events , a groundbreaking concept
Indeed, there are multiple primary or secondary bile acid chemosensors in the liver (348, 354) or scattered along the gastrointestinal tract (355), where they ensure a direct negative feedback aiding detoxification (356) and protecting from hepatotoxicity and carcinogenicity displayed by some secondary bile salt such as lithocholic acid
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How semaglutide should best be used for long-term weight management remains to be seen, as many people who stop taking the drug have regained the weight
Additionally, all participants in the highest-dose group achieved at least 5% weight loss, with 26% of participants losing 30% or more of their baseline weight [R]
