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IGF-1 is the anchor metric community sources describe a 20-40% increase from baseline as the sign the protocol is working even when visual changes are minimal

Advanced Timing Strategies for Different Goals For Fat Loss and Body Recomposition When fat loss is the primary goal, the best time to take Ipamorelin shifts toward maximizing metabolic benefits: Optimal protocol: Primary : Morning fasted injection (200-300 mcg) Secondary : Pre-bed injection (200 mcg) Frequency : 5-6 days per week Cycle length : 12-16 weeks This approach leverages Ipamorelin's fat-oxidizing properties during the day while supporting recovery at night

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