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With GLP-1 therapy Diet & exercise alone No intervention At 3 months ~5% average body weight loss* At 6 months ~10% average body weight loss* At 1 year ~15% average body weight loss* *Based on STEP 1 clinical trial data (semaglutide 2.4mg + lifestyle intervention)

GPs normally give these every 12 weeks, but the effects wear off before this and as a result the patient is left feeling sluggish and run down

10.1016/S0735-1097(00)00748-8 83

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Decades of uncomfortable bouts of irritable bowel syndrome relieved

Additionally, questions exist about potential effects in this population, including the impact of rapid weight loss on skin elasticity and lymphatic function in areas already affected by tissue changes