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It can also increase the risk of side effects when treatment is restarted

That figure is not unique to GLP-1 medications, some lean tissue loss accompanies most significant weight loss, but the pace and scale of GLP-1-driven weight loss makes the risk more acute

10.3 Pancreatitis & retinopathy risk Reports of pancreatitis and gastrointestinal intolerance, though infrequent, remain notable in real-world settings

While some people notice changes within the first few months, the greatest benefits are typically seen with long-term use alongside a healthy diet and regular exercise

Animal studies show mostly mild local irritation at injection sites

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